Effect of low dose dopamine on early graft function in living unrelated kidney
donors.
Author(s): Hosseinzadeh H, Golzari S, Abravesh M, Mahmoodpoor A, Aghamohammadi D, Zomorrodi
A, Hosseinzadeh P.
Affiliation(s): Department of Anesthesiology, Imam Khomeini Hospital, Faculty of Medicine, Tabriz
University of Medical Sciences, Tabriz, Iran.
Publication date & source: 2012, Urol J. , 9(1):389-96
PURPOSE: To evaluate the effect of low-dose dopamine administration on the early
function of the kidney in unrelated kidney donors after transplantation.
MATERIALS AND METHODS: In this double-blinded clinical trial, 60 adult kidney
donors and 60 recipients, younger than 50 years old, were studied. Donors and
recipients were randomly divided into two groups; group 1 received dopamine 3
µ/kg/min and group 2 received similar regimen of placebo. During the first 3 days
postoperatively, serum levels of urea and creatinine as well as urine output and
early kidney function were compared between two groups.
RESULTS: Serum levels of creatinine and urea and urine output during the first
three days after the operation did not differ statistically significantly between
two groups (P = .549, P = .306, and P = .375, respectively). Early kidney
function was better significantly in group 1 (5.3 ± 3.2 versus 8.6 ± 8.0 hours; P
= .048).
CONCLUSION: Premedication of the kidney transplant donors with low-dose dopamine
accelerates early kidney function after transplantation, but has no effect on the
hemodynamic status and serum levels of creatinine and urea in the donors.
|