Effect of the Honan intraocular pressure reducer to prevent vitreous reflux after
intravitreal bevacizumab injection.
Author(s): Hong SW, Jee D.
Affiliation(s): Department of Ophthalmology and Visual Science, Bucheon St. Mary's Hospital,
Publication date & source: 2012, Eur J Ophthalmol. , 22(4):615-9
PURPOSE: To evaluate the effect of the Honan intraocular pressure reducer (HIPR)
on vitreous reflux during intravitreal (IVT) injection.
METHODS: Prospective, comparative, controlled, investigator-blinded, randomized
clinical study. Sixty eyes of 60 patients who underwent IVT injection were
allocated into 2 groups with or without using the HIPR. Vitreous reflux was
estimated by measuring largest diameter of the conjunctival bleb formed after IVT
injection. Preoperative intraocular pressure (IOP) before and after application
of the HIPR and IOP immediately postoperatively and 3 and 10 minutes
postoperatively were evaluated.
RESULTS: The mean amount of vitreous reflux was significantly less with the HIPR
than without the HIPR (1.46±1.04 mm vs 2.61±1.37 mm; p<0.001). The preoperative
IOP was significantly lower with the HIPR than without the HIPR (11.62±4.04 mmHg
vs 16.26±3.86 mmHg; p=0.026). The 3-minute postoperative IOP was 31.34±3.16 mmHg
with the HIPR and 32.61±5.62 mmHg without the HIPR (no statistical significance;
CONCLUSIONS: The HIPR prevents vitreous reflux after IVT through a reduction in
the preoperative IOP. However, the HIPR appears not to affect the postoperative
course of transient IOP elevation.