Trospium chloride--an effective drug in the treatment of overactive bladder and detrusor hyperreflexia.

Author(s): Hofner K, Oelke M, Machtens S, Grunewald V

Affiliation(s): Urologische Klinik, Ev Krankenhaus Oberhausen, Germany. klaus.hoefner@freenet.de

Publication date & source: 2001-11, World J Urol., 19(5):336-43.

Publication type: Review

Trospium chloride (TCL), a quaternary ammonium derivative of nortropanol, has been evaluated in a number of clinical and pharmacological studies. Selected pharmacological and clinical pharmacokinetic data are discussed as providing a basis for a better interpretation and understanding of the clinical trial results. An overview of the results of 20 clinical trials and post-marketing surveillance studies including more than 10000 patients is presented.