Propofol versus thiopental: effects on peri-induction intraocular pressures in normal dogs.
Author(s): Hofmeister EH, Williams CO, Braun C, Moore PA
Affiliation(s): Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA. firstname.lastname@example.org
Publication date & source: 2008-07, Vet Anaesth Analg., 35(4):275-81. Epub 2008 Feb 18.
Publication type: Comparative Study; Randomized Controlled Trial
OBJECTIVE: To determine the effects of propofol or thiopental induction on intraocular pressures (IOP) in normal dogs. STUDY DESIGN: Prospective randomized experimental study. ANIMALS: Twenty-two random-source dogs weighing 19.5 +/- 5.3 kg. METHODS: Dogs were randomly assigned to receive propofol 8 mg kg(-1) IV (group P) or thiopental 18 mg kg(-1) IV (group T) until loss of jaw tone. Direct arterial blood pressure, arterial blood gasses, and IOP were measured at baseline, after pre-oxygenation but before induction, before endotracheal intubation, and after intubation. RESULTS: There were no significant differences between groups with regard to weight, body condition score, breed group, or baseline or before-induction IOP, arterial blood pressure, or blood gases. The baseline IOP was 12.9 mmHg. Before endotracheal intubation, IOP was significantly higher compared to baseline and before induction in dogs receiving propofol. After intubation with propofol, IOP was significantly higher compared to thiopental and was significantly higher compared to before induction. After intubation, IOP was significantly lower compared to before intubation in dogs receiving thiopental. Propofol increased IOP before intubation by 26% over the before-induction score and thiopental increased IOP by 6% at the same interval. The IOP in group P remained 24% over the before induction score whereas thiopental ultimately decreased IOP 9% below baseline after intubation. There was no significant relationship between any cardiovascular or blood gas parameter and IOP at any time. There was no significant relationship between the changes in any cardiovascular or blood gas parameter and the changes in IOP between time points. CONCLUSIONS AND CLINICAL RELEVANCE Propofol caused a significant increase in IOP compared to baseline and thiopental. Thiopental caused an insignificant increase in IOP which decreased after intubation. Propofol should be avoided when possible in induction of anesthesia in animals where a moderate increase in IOP could be harmful.