Pharmacology of antiretroviral drugs.

Author(s): Hoetelmans RM

Affiliation(s): Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands. APRHT@SLZ.NL

Publication date & source: 1999, Antivir Ther., 4 Suppl 3:29-41.

Publication type: Review

In this paper, an overview of the pharmacokinetics of currently available antiretroviral drugs is provided. Included in this article are the agents zidovudine, stavudine, zalcitabine, lamivudine, didanosine, abacavir, nevirapine, delavirdine, efavirenz, saquinavir, indinavir, ritonavir and nelfinavir. Key pharmacokinetic parameters, drug penetration in body compartments and drug interactions are discussed for each agent.