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Randomized controlled trial of vaginal misoprostol versus vaginal misoprostol and isosorbide dinitrate for termination of pregnancy at 13-29 weeks.

Author(s): Hidar S, Bouddebous M, Chaieb A, Jerbi M, Bibi M, Khairi H

Affiliation(s): Department of Obstetrics and Gynaecology, Farhat Hached University Teaching Hospital, 4002, Sousse, Tunisia. hidar.samir@gnet.tn

Publication date & source: 2005-12, Arch Gynecol Obstet., 273(3):157-60. Epub 2005 Jul 24.

Publication type: Randomized Controlled Trial

When compared to the use of 12 hourly 200 microg vaginal misoprostol on its own, the addition of a single dose of 5 mg did not significantly increase the abortion or delivery rate in pregnancy termination at 13-29 weeks gestation. All patients were given intravenous syntocinon at 30 mU/min from the first dose of misoprostol onwards.

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