[Mixed vaginitis prevalence in Latin-American women, according to physician perception. Preference, effectiveness and security of clindamycin plus ketoconazole]

Author(s): Hernandez Bueno JA, Vazquez Alanis A, Olguin Ramirez C, Dumet Hinostroza PF, Gutierrez Ramos M, De Zordo D

Affiliation(s): Clinica de Atencion Medica Integral para la Mujer SC, Naucalpan, Estado de Mexico, Mexico. jhernandezb@atmim.com

Publication date & source: 2008-11, Ginecol Obstet Mex., 76(11):652-8.

Publication type: English Abstract; Multicenter Study

BACKGROUND: Vaginitis is an inflammatory process in vaginal mucosa that affects millions of woman worldwide. OBJECTIVE: To evaluate prevalence perception and prescription preference among Latin-American gyneco-obstetricians in mixed vaginitis, and to identify attributes of various active principles. MATERIAL AND METHODS: multicentric and transversal study during January 2008. Close Up was used to poll gyneco-obstetricians prescribing clyndamicin plus ketoconazole. 1,198 gyneco-obstetricians were selected to answer a poll (scales and measuring attributes) to identify differences among various therapeutic schemes to mixed vaginitis. RESULTS: 34% of gyneco-obstetricians consider that 30 to 50% of them patients had mixed vaginitis, 38% consider a 50 to 70% of its prevalence, and 20% a 70% or higher figure. In a bad to excellent scale, 97% had very good to excellent results with antimycotic and antibacterial mix, 73% had a bad to good result with antimycotics alone and 79% with antibacterial alone. Clyndamicin plus ketoconazole had a meaningful difference from mean results (standard), and from the second best mix (metronidazole plus nystatin), with a rapid itch healing, efficacy, and relapse decrease. Metronidazole plus nystatin had the highest score in tolerance and treatment period. CONCLUSION: 90% of polled Latin-American obstetricians prescribe clyndamicin plus ketoconazole as the best available treatment to mixed vaginitis.