Oseltamivir and risk of lower respiratory tract complications in patients with flu symptoms: a meta-analysis of eleven randomized clinical trials.
Author(s): Hernan MA, Lipsitch M
Affiliation(s): Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA. miguel_hernan@post.harvard.edu
Publication date & source: 2011-08-01, Clin Infect Dis., 53(3):277-9. Epub 2011 Jun 15.
Publication type: Meta-Analysis; Research Support, N.I.H., Extramural
An independent reanalysis of 11 randomized clinical trials shows that oseltamivir treatment reduces the risk of lower respiratory tract complications requiring antibiotic treatment by 28% overall (95% confidence interval [CI], 11%-42%) and by 37% among patients with confirmed influenza infections (95% CI, 18%-52%).
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