Protective efficacy of lambda-cyhalothrin treated nets in anopheles gambiae pyrethroid resistance areas of Cote d'Ivoire.

Author(s): Henry MC, Assi SB, Rogier C, Dossou-Yovo J, Chandre F, Guillet P, Carnevale P

Affiliation(s): Institut Pierre Richet, Bouake, Cote d'Ivoire. depauw.henry@fasonet.bf

Publication date & source: 2005-11, Am J Trop Med Hyg., 73(5):859-64.

Publication type: Clinical Trial, Phase III

The efficacy of nets treated with lambda-cyhalothrin, a pyrethroid insecticide, on malaria infection and disease was assessed for the first time at the community level in Anopheles gambiae pyrethroid resistance areas. The study was carried out in northern Cote d'Ivoire, which is an area of kdr resistance. Four pairs of villages were selected and matched according to demographic, sociological, and ecological criteria. Among each pair, a village was randomly allocated to receive mosquito nets. More than 80% of beds were covered with nets treated with lambda-cyhalothrin and retreated after 6 months. In each village, 54 children aged 0-59 months were randomly selected and clinically monitored for 8 periods of 7 days throughout the year. Results showed that the efficacy of treated nets was maintained with a reduction of the prevalence of asymptomatic malaria infection by 12% and an estimated protective efficacy against malaria disease of 56%.