[The calcipotriol-betamethasone dipropionate association]

Author(s): Henry F, Flagothier C, Delvoye P, Pierard-Franchimont C, Pierard GE

Affiliation(s): CHU du Sart Tilman, Service de Dermatopathologie, Liege.

Publication date & source: 2005-11, Rev Med Liege., 60(11):893-5.

Publication type: Review

The topical treatment of psoriasis benefits from the alternate use of dermocorticosteroids and vitamin D3 analogues. A new galenic formulation allows to combine them in a single application. Dovobet (LEO Pharma) ointment is the association of calcipotriol 50 microg/g with betamethasone dipoprionate 0.5 mg/g. This formulation boosts the therapeutic activity of calcipotriol. It also decreases the irritative inflammatory reaction due to calcipotriol without increasing the atrophogenic risk of the dermocorticoid.