[Effects of flurazepam on disturbed sleep in patients with AIDS]

Author(s): Henkes H, Kubicki S, Hansen ML, Terstegge K, Scholz G, Ruhnke M

Affiliation(s): Abteilung fur Klinische Neurophysiologie, Freien Universitat Berlin.

Publication date & source: 1989-12, EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb., 20(4):295-301.

Publication type:

Polysomnograms were recorded of twelve patients with acquired immune deficiency syndrome (AIDS) during different stages in an open design. During the first night no hypnotics were administered, during the second night 30 mg flurazepam per os were given. Flurazepam affected mainly the NREM parameters. The times "awake" during the night were reduced, sleep stage 2 showed an increase, and the effective sleep time was also increased. The increase in sleep spindle density was remarkable, however, delta sleep and generation of K-complexes were not affected. Flurazepam did not affect REM sleep at all. The amount of REM sleep showed a slight increase. REM distribution during the night did not show the "bell shaped" increase and the decrease in the morning; the degree of the illness correlated with a flattening of REM distribution.