The topical effect of grape seed extract 2% cream on surgery wound healing.
Author(s): Hemmati AA(1), Foroozan M, Houshmand G, Moosavi ZB, Bahadoram M, Maram NS.
Affiliation(s): Author information:
(1)Medical Student, Ahvaz Jundishapur University of Medical Sciences, Ahvaz-
Iran. mohammadbahadoram@yahoo.com.
Publication date & source: 2014, Glob J Health Sci. , 7(3):52-8
BACKGROUND: Reducing the wound healing time is crucial in wound as it lowers the
chance of infection and decreases complications and cost. Grape seed extract has
the ability to release endothelial growth factor and its topical application
results in contraction and closure of the skin wound. Furthermore, it possesses
antioxidant and antibacterial properties. In several studies it has been proved
effective in animals. Therefore, due to low side effects and recognition of
herbal medicine, we decided to evaluate the effect of grape seed extract 2%
herbal cream on human skin lesions.
MATERIALS: This study is a double blind clinical trial conducted on two groups of
treatment and placebo. Surgery was performed on skin lesions such as skin tags
and moles which were found on the neck, trunk and limbs (except for face). After
enrollment and obtaining informed consent from participants, they were randomized
into two groups of treatment and placebo. Excision of the lesions was done by
surgical scissors. The lesions got restored by secondary intention method. After
the first day of treatment, the patients were visited on the 3rd, 7th, 10th,
14th, and 21st day. Grape seed extract cream 2% was produced and coded by the
Faculty of Pharmacy, Ahvaz University of Medical Sciences. In order to compare
the two groups, T-test was used. For time assessing, analysis of variance with
repeated measures was employed.
RESULTS: The results showed complete repair of wounds averagely on day 8 for the
treatment group and on day 14 for the placebo group, which was clearly
significant in terms of statistical difference (p=0.00).
CONCLUSION: Proanthocyanidins in grape seed extract trigger the release of
vascular endothelial growth factor and its topical application causes wound
contraction and closure. Curing skin lesions with grape seed extract caused
proliferation areas with protected boundaries in epithelium, increased cell
density and increased deposition of connective tissue at the wound site which in
general improves cellular structure in wound. In addition, its anti-inflammatory
and anti-microbial properties are effective in wound healing.
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