Long-term results in patients with onychomycosis treated with terbinafine or itraconazole.

Author(s): Heikkila H, Stubb S

Affiliation(s): Department of Dermatology and Venereology, Helsinki University Central Hospital, Meilahdentie 2, 00250 Helsinki 25, Finland. hannele.heikkila@hus.fi

Publication date & source: 2002-02, Br J Dermatol., 146(2):250-3.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

BACKGROUND: Previously, a double-blind, randomized, multicentre study (LION study) compared the efficacy of continuous terbinafine 250 mg daily for 3 or 4 months with itraconazole pulse therapy 400 mg daily for 3 or 4 months. At the end of the study at week 72 terbinafine proved to be more effective. OBJECTIVES: To perform a 4-year follow-up of the Finnish participants in this study. METHODS: Patients were re-examined clinically and mycologically. RESULTS: Complete clinical and mycological cure with terbinafine for 4 months was 78% compared with 35% with terbinafine for 3 months, 24% with itraconazole for 4 months and 28% with itraconazole for 3 months. CONCLUSIONS: These results suggest that the initial treatment for onychomycosis should be a 4-month continuous course of terbinafine.