Dezocine pretreatment prevents myoclonus induced by etomidate: a randomized,
double-blinded controlled trial.
Author(s): He L(1), Ding Y, Chen H, Qian Y, Li Z.
Affiliation(s): Author information:
(1)Department of Anesthesiology, The Second Affiliated Hospital of Nanjing
Medical University, Nanjing, 210011, China.
Publication date & source: 2015, J Anesth. , 29(1):143-5
The aim of this randomized, double-blind, placebo-controlled clinical trial was
to evaluate the effects of dezocine on the incidence and severity of myoclonus
induced by etomidate. Patients (108) were randomly assigned to one of two groups
to receive either 0.1 mg kg(-1) of dezocine (n = 54; Group D) or saline (n = 54;
Group S) intravenously 1 min before 0.3 mg kg(-1) etomidate was given. The
occurrence and severity (observational score of 0-3) of myoclonus was assessed
for 2 min after administration of etomidate. The incidence and the intensity of
myoclonus were significantly lower in Group D (0 %) than in Group S (75.9 %) (P <
0.01), and all patients showed stable cardiovascular profiles. The results
suggest that infusion of 0.1 mg kg(-1) dezocine 1 min before etomidate
administration is effective for suppressing myoclonus induced by etomidate during
induction of general anesthesia without significant side-effects.
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