The effect of vitamin A supplementation on disease progression, cytokine levels
and gene expression in multiple sclerotic patients: study protocol for a
randomized controlled trial.
Author(s): Harrirchian MH(1), Mohammadzadeh Honarvar N(2), Koohdani F(2), Bitarafan S(2),
Siassi F(3), Jafarirad S(4), Abdolahi M(2), Salehi E(5), Saharian MA(6),
Rouystaee H(7), Eshraghian MR(8), Saboor-Yarghi AA(9).
Affiliation(s): Author information:
(1)Iranian Center for Neurological Research, Tehran University of Medical
Sciences, Tehran, Iran. asaboor@tums.ac.ir. (2)Department of Cellular and
Molecular Nutrition, Faculty of Nutritional Sciences and Dietetics, Tehran
University of Medical Sciences, Tehran, Iran. asaboor@tums.ac.ir. (3)Community
Nutrition Department, Faculty of Nutritional Sciences and Dietetics, Tehran
University of Medical Sciences, Tehran, Iran. asaboor@tums.ac.ir. (4)Department
of Cellular and Molecular Nutrition, Faculty of Nutritional Sciences and
Dietetics, Tehran University of Medical Sciences, Tehran, Iran. & Department of
Nutrition, Faculty of Paramedicine, Jundishapur University of Medical Sciences,
Ahvaz, Iran. asaboor@tums.ac.ir. (5)Immunology Department, Faculty of Medicine,
Tehran University of Medical Sciences, Tehran, Iran. asaboor@tums.ac.ir.
(6)Department of Neurology, Sina Hospital, Tehran, Iran. asaboor@tums.ac.ir.
(7)Medicine faculty, Tehran University of Medical Sciences, Tehran, Iran.
asaboor@tums.ac.ir. (8)Department of Biostatistics, Faculty of Public Health,
Tehran University of Medical Sciences, Tehran, Iran. asaboor@tums.ac.ir.
(9)Department of Cellular and Molecular Nutrition, Faculty of Nutritional
Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. &
Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran,
Iran. asaboor@tums.ac.ir.
Publication date & source: 2014, Acta Med Iran. , 52(2):94-100
Multiple Sclerosis (MS) is a chronic inflammatory disease that leads to
degeneration of the brain and spinal tissue. Imbalances of CD4+ T cells including
Thelper1 (Th1)/Thelper2 (Th2) and Thelper17 (Th17)/Tregulatory (Treg), their
secreted cytokines and gene expressions, are important aspects of in
immunopathogenesis of MS. Vitamin A and its metabolites can regulate the immune
system and appears to be effective in preventing progression of the autoimmune
disease such as MS. Disease progression was evaluated By Magnetic Resonance
Imaging (MRI), Expanded Disability States Scale (EDSS) and Multiple Sclerosis
Functional Composite (MSFC) tests. Cytokine levels were measured using ELISA kits
and gene expression was quantified by Real time PCR (RT-PCR) system. According to
the difference between the epidemiological and clinical data on the relationship
between vitamin A and immune system regulation, this study of the first time
assesses Immune function as well as gene expression and progression of the
disease following administration of vitamin A supplement.
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