Hypothyroidism and dyshormonogenesis induced by D-penicillamine in children with Wilson's disease and healthy infants born to a mother with Wilson's disease.

Author(s): Hanukoglu A, Curiel B, Berkowitz D, Levine A, Sack J, Lorberboym M

Affiliation(s): Division of Pediatric Endocrinology, E. Wolfson Medical Center, Holon, Israel; Tel-Aviv University, Sackler School of Medicine, Israel.

Publication date & source: 2008-12, J Pediatr., 153(6):864-6.

Publication type:

Two siblings born to a mother with Wilson's disease, who was taking D-penicillamine, developed transient goitrous hypothyroidism. A prospective evaluation of 5 patients with Wilson's disease taking and not taking D-penicillamine for as long as 9.5 years showed subclinical hypothyroidism. D-penicillamine probably inhibited thyroperoxidase activity in utero in healthy infants and during childhood in patients with Wilson's disease.