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Once-weekly oral medication with alendronate does not prevent migration of knee prostheses: A double-blind randomized RSA study.

Author(s): Hansson U, Toksvig-Larsen S, Ryd L, Aspenberg P

Affiliation(s): Department of Orthopedics, Lund University Hospital, Lund, Sweden. ulrik.hansson@med.lu.se

Publication date & source: 2009-02, Acta Orthop., 80(1):41-5.

Publication type: Randomized Controlled Trial

BACKGROUND AND PURPOSE: Early migration of joint replacements is an effect of poor fixation and can predict late loosening. By reducing the bone resorption after implantation of a joint replacement, it should be possible to enhance the initial fixation of the implant. We studied the effect of once-weekly treatment with alendronate after knee replacement. PATIENTS AND METHODS: We recruited 60 patients (60 knees) with gonarthrosis who were scheduled for a total knee replacement. They were operated on with identical implants and uncemented fixation. 30 patients were treated with a bisphosphonate (alendronate) and 30 patients underwent placebo treatment. The treatment started postoperatively and continued on a weekly basis for 6 months. The fixation of the implants was measured with repeated radiostereometry for 2 years. RESULTS: There was no difference in migration of implants between the two groups. CONCLUSION: With uncemented fixation of knee implants, no benefit of once-weekly treatment with alendronate, starting postoperatively, could be seen during a 2-year follow-up period.

Page last updated: 2009-10-20

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