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Is pertussis immune globulin efficacious for the treatment of hospitalized infants with pertussis? No answer yet.

Author(s): Halperin SA, Vaudry W, Boucher FD, Mackintosh K, Waggener TB, Smith B, Pediatric Investigators Collaborative Network on Infections in Canada

Affiliation(s): Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada. scott.halperin@dal.ca

Publication date & source: 2007-01, Pediatr Infect Dis J., 26(1):79-81.

Publication type: Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

In a multicenter, randomized, placebo-controlled clinical trial of pertussis immune globulin, intravenous (P-IGIV), 25 infants hospitalized with pertussis were enrolled in 24 months (15% of the target sample size) before the study was prematurely terminated because of expiration of the P-IGIV lots and unavailability of additional study product. Although well tolerated, there was no difference in the number or rate of improvement of symptoms (paroxysmal cough, whoop, apnea, bradycardia, oxygen desaturations) in P-IGIV recipients compared with placebo.

Page last updated: 2007-02-12

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