Intravenous infusions of ifosfamide/mesna and perturbation of warfarin anticoagulant control.

Author(s): Hall G, Lind MJ, Huang M, Moore A, Gane A, Roberts JT, Cantwell BM

Affiliation(s): University Department of Clinical Oncology, Newcastle General Hospital, Newcastle upon Tyne, UK.

Publication date & source: 1990-10, Postgrad Med J., 66(780):860-1.

Publication type: Case Reports

We report three patients who had serious disturbance of anticoagulant control while receiving ifosfamide/mesna-containing cytotoxic chemotherapy in association with warfarin. In view of the likely biological potentiation of warfarin by ifosfamide/mesna, close monitoring of anticoagulant control should be performed during the co-administration of these drugs.