Pharmacokinetics and relative bioavailability of nimodipine capsules and tablets in 8 Chinese healthy men.
Author(s): Guo LQ, Tan HS, Chen G
Affiliation(s): Department of Clinical Pharmacology, Jinling Hospital, Nanjing, China.
Publication date & source: 1993-07, Zhongguo Yao Li Xue Bao., 14(4):295-7.
Publication type: Clinical Trial; Randomized Controlled Trial
A single oral dose of tablets or capsules of 239 mumol nimodipine was given to 8 healthy volunteers of Han nationality in a randomized crossover study. Plasma levels were determined with HPLC method. The plasma concentration-time curve fitted to a first order absorption, 1-compartment open model, and the T1/2K was around 2 h. Although the capsules could reach peak level faster, the bioavailability was not significantly different from that of the tablets.
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