Disseminated invasive aspergillosis with cerebral involvement successfully treated with caspofungin and voriconazole.

Author(s): Gubler C, Wildi SM, Imhof A, Schneemann M, Mullhaupt B

Affiliation(s): Dept. of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich, Switzerland. christoph.gubler@spitaluster.ch

Publication date & source: 2007-10, Infection., 35(5):364-6. Epub 2007 Aug 25.

Publication type: Case Reports

We describe a case of cerebral aspergillosis which was successfully treated with a combination of caspofungin and voriconazole. The patient remains in remission 18 months after stopping antifungal treatment. We discuss primary and salvage therapy of invasive aspergillosis with focus on cerebral involvement. Since historical data showed a fatal outcome in most cases, amphotericin B does not cross the blood brain barrier while voriconazole does, we chose a combination of voriconazole plus caspofungin as primary therapy.