[Comparison of linezolid and vancomycin in nosocomial pneumonia: results of the multicenter double-blind study]

Author(s): Grudinina SA, Zubkov MM, Krotova LA, Kurdiukova IuP, Kutsenko MA, Marinin VF, Sidorenko SV, Sinpal'nikov AI, Solomatin AS, Sterkhova GV, Fesenko OV, Fomina IG, Chuchalin AG

Affiliation(s): National Research Centre of Antibiotics, Municipal Clinical Hospital No. 61.

Publication date & source: 2002, Antibiot Khimioter., 47(1):12-7.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The results of multicenter, randomized, double-blind comparative study of linezolid and vancomycin efficacy, safety and tolerability in the treatment of nosocomial pneumonia are presented. The trial was performed on 69 patients. Clinical efficacy of linezolid was 83 per cent, of vancomycin--79 per cent. Bacteriological effect (pathogen eradication) was 83 per cent for linezolid group and 86 per cent for vancomycin group. During the study good clinical tolerability of linezolid was demonstrated along with lower side effects incidence and shortened recovery period when compared to vancomycin.