Field evaluation of moxidectin/praziquantel oral gel in horses.

Author(s): Grubbs ST, Amodie D, Rulli D, Wulster-Radcliffe M, Reinemeyer C, Yazwinski T, Tucker C, Hutchens D, Smith L, Patterson D

Affiliation(s): Fort Dodge Animal Health, PO Box 5366, Princeton, NJ 08543, USA.

Publication date & source: 2003-09, Vet Ther., 4(3):249-56.

Publication type: Clinical Trial; Multicenter Study; Randomized Controlled Trial

The safety and efficacy of 2% moxidectin/12.5% praziquantel oral gel administered at a rate of 0.4 mg moxidectin and 2.5 mg praziquantel/kg was studied in client-owned horses under field use conditions. Four hundred horses (300 treated with moxidectin/praziquantel oral gel and 100 treated with vehicle) were enrolled, feces were collected, and eggs were counted. Investigators as well as horse owners were masked to treatment assignment. No adverse reactions to treatment were observed in any horses. Moxidectin/praziquantel gel reduced Anoplocephala spp by more than 99% and provided a significant (P <.05) reduction (> 98%) in the strongyle egg count of treated horses.