Acute hepatitis and atovaquone/proguanil.

Author(s): Grieshaber M, Lammli J, Marcus L

Affiliation(s): Department of Opthamology, Medical University of Southern Africa, Medunsa, South Africa.

Publication date & source: 2005-09, J Travel Med., 12(5):289-90.

Publication type: Case Reports

A 31-year-old healthy man developed acute hepatitis after receiving atovaquone (250 mg) and proguanil (100 mg) for malaria prophylaxis daily for 25 days. Although atovaquone/proguanil is generally well-tolerated, this case highlights the hepatotoxic potential with considerable morbidity and should alert physicians to this harmful side effect.