Leukodepletion and aprotinin improve clinical outcome after extracorporeal circulation.
Author(s): Gott JP
Affiliation(s): Fuqua Heart Center, Piedmount Hospital, Atlanta, Georgia 30309, USA. gottjp@aol.com
Publication date & source: 2001-03, Perfusion., 16 Suppl:5-9.
Publication type: Clinical Trial; Randomized Controlled Trial
Most cardiac operations involve the use of extracorporeal circulation with its attendant systemic inflammatory response syndrome. Many anti-inflammatory strategies hold promise for reducing the associated morbidity of cardiopulmonary bypass. The application of pharmacological and mechanical strategies to control this inflammatory response now has demonstrable clinical benefit. The additional costs of these successful strategies are offset by the economic savings and improved quality of care.
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