Ifosfamide-induced encephalopathy.

Author(s): Gonzalez-Angulo AM, Orzano JA, Davila E

Affiliation(s): Department of Medicine, Mount Sinai Medical Center, Miami Beach, Fla 33140, USA.

Publication date & source: 2002-10, South Med J., 95(10):1215-7.

Publication type: Case Reports

A 46-year-old man with a history of metastatic transitional cell carcinoma of the bladder received treatment with ifosfamide/mesna. He had reversible encephalopathy after the first cycle of chemotherapy. Adequate clinical response was achieved, with an obvious decrease in tumor size. Subsequently, an identical treatment was given without adverse central nervous system effects. Few data exist about retreatment with intravenous ifosfamide/mesna after induced encephalopathy, but this case suggests that this adverse effect may not recur in some patients.