Pemphigus vulgaris triggered by glibenclamide and cilazapril.

Author(s): Goldberg I, Sasson A, Gat A, Srebrnik A, Brenner S

Affiliation(s): Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.

Publication date & source: 2005, Acta Dermatovenerol Croat., 13(3):153-5.

Publication type: Case Reports

A case of pemphigus triggered by glibenclamide and cilazapril is described. The suspicion of drug induction was confirmed in a laboratory study in which a pemphigus-like effect was induced by glibenclamide in cultured human skin explants. Withdrawal of the drugs and their replacement by hydrochlorothiazide and metformin resulted in subsidence of the lesions and no appearance of new lesions. The laboratory study carried out to verify the suspicion of drug induced pemphigus and to confirm the diagnosis proved useful in the differential diagnosis in this case.