High-dose verapamil + trandolapril-induced thrombotic microangiopathy.

Author(s): Gokel Y, Paydas S, Acikalin A, Bozkurt A

Affiliation(s): Department of Emergency Medicine, Faculty of Medicine, Cukurova University, Adana, Turkey. ygokel@mail.cu.edu.tr

Publication date & source: 2002, Haematologia (Budap)., 32(3):281-5.

Publication type: Case Reports

Thrombotic microangiopathy (TMA) is a syndrome characterized by microangiopathic haemolytic anaemia, thrombocytopenia, and several variable signs of organ damage due to the platelet thrombi in the microcirculation. This article reports a case with TMA which developed after ingestion of a high-dose combination of verapamil and trandolapril. To the authors' knowledge, no prior cases of TMA induced by trandolapril (an angiotensin-converting enzyme inhibitor) and verapamil (a calcium channel blocker) have been reported in the literature.