Safety and efficacy of rivaroxaban for thromboprophylaxis following lower limb
surgery: an update.
Author(s): Goff T, Kontakis G, Giannoudis PV.
Affiliation(s): Academic Unit of Trauma and Orthopaedic Surgery, Academic Unit, Clarendon Wing,
Leeds Teaching Hospitals Trust, Great George Street, West Yorkshire, Leeds, LS1
3EX, UK.
Publication date & source: 2011, Expert Opin Drug Saf. , 10(5):687-96
INTRODUCTION: Thromboprophylaxis in orthopedic surgery remains a controversial
issue despite recent changes to NICE guidelines, particularly with the addition
of oral factor Xa inhibitors. The healthcare burden of venous thromboembolism is
substantial and needs frequent academic and clinical appraisal. AREAS COVERED:
The authors review the available relevant literature on the use of rivaroxaban in
orthopedic surgery, identified using an EMBASE (1980 - 2010) and Ovid MEDLINE
(1950 - 2010) search of published articles up to August 2010. This includes
clinical studies, case reports and experimental studies where applicable. Search
terms include: 'rivaroxaban', 'safety', 'efficacy', 'bleeding', 'toxicity',
'tolerability' and 'complication'. EXPERT OPINION: Rivaroxaban is a safe and
effective choice of thromboprophylactic agent following lower limb arthroplasty
surgery. More research is required to expand the application of this novel agent
to other areas of orthopedic surgery.
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