Efficacy of ketamine and midazolam as co-induction agents with propofol for laryngeal mask insertion in children.

Author(s): Goel S, Bhardwaj N, Jain K

Affiliation(s): Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Publication date & source: 2008-07, Paediatr Anaesth., 18(7):628-34. Epub 2008 May 8.

Publication type: Randomized Controlled Trial

OBJECTIVES: Use of midazolam and ketamine lowers the induction dose of propofol (co-induction) producing hemodynamic stability. BACKGROUND: Large doses of propofol needed for induction and laryngeal mask (LM) insertion in children may be associated with hemodynamic and respiratory effects. Co-induction has the advantage of reducing dose and therefore maintaining hemodynamic stability. AIM: To examine the effect of co-induction on hemodynamics, LM insertion and recovery in children. METHODS/MATERIALS: A prospective, randomized, double-blind, controlled study was conducted in 60 ASA I/II children, age 1-8 years. Normal saline, ketamine 0.5 mg.kg(-1), midazolam 0.05 mg.kg(-1) were administered in groups P (propofol), PK (propofol-ketamine) and PM (propofol-midazolam), respectively, 2 min prior to the administration of the induction dose of propofol. Propofol 3.5 mg.kg(-1) (group P) or 2.5 mg.kg(-1) (groups PK and PM) was used for induction, LM inserted 30 s later and insertion conditions assessed. Heart rate and blood pressure were recorded immediately after propofol bolus, then every min till 2 min after LMA insertion. Recovery was assessed using Steward's Score. RESULT: In group P, systolic blood pressure (SBP) showed a significantly greater decrease compared to group PK and group PM (P < 0.005). Only 5% of patients in groups PK and PM showed >20% fall in SBP compared to 89% in group P (P < 0.005). More children in groups PK and PM had acceptable conditions for LM insertion compared to group P (P < 0.05). The time to achieve Steward Score of 6 was longer in groups PK and PM compared to group P (P < 0.005). CONCLUSION: In children, the combination of propofol with ketamine or midazolam produces stable hemodynamics and improved LM insertion conditions but is associated with delayed recovery.