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A placebo-controlled clinical trial to compare a gel containing a combination of isotretinoin (0.05%) and erythromycin (2%) with gels containing isotretinoin (0.05%) or erythromycin (2%) alone in the topical treatment of acne vulgaris.

Author(s): Glass D, Boorman GC, Stables GI, Cunliffe WJ, Goode K

Affiliation(s): Department of Dermatology, General Infirmary at Leeds, Maidenhead, UK.

Publication date & source: 1999, Dermatology., 199(3):242-7.

Publication type: Clinical Trial; Randomized Controlled Trial

PURPOSE: To compare the clinical benefit of isotretinoin (0.05%) and erythromycin (2%) gels alone and in combination (Isotrexintrade mark) in acne patients. PROCEDURE: The study was a randomised placebo-controlled trial in acne patients who should benefit from topical therapy. RESULTS: All treatment groups except placebo produced a time-related reduction in lesion counts, with the combined therapy producing the largest mean decrease. Between-group comparisons showed several significant differences. CONCLUSION: Isotrexin was significantly better than placebo at all time points for inflamed and total lesions, and was better than isotretinoin at week 4. Side-effects were minimal.

Page last updated: 2006-01-31

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