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Effect of intravenous propofol and remifentanil on heart rate, blood pressure and nociceptive response in acepromazine premedicated dogs.

Author(s): Gimenes AM, de Araujo Aguiar AJ, Perri SH, de Paula Nogueira G

Affiliation(s): Department of Veterinary Surgery and Anaesthesiology, Faculty of Veterinary Medicine and Animal Science, Sao Paulo State University (UNESP), Botucatu, Sao Paulo, Brazil. andre_gimenes@hotmail.com

Publication date & source: 2011-01, Vet Anaesth Analg., 38(1):54-62.

Publication type: Randomized Controlled Trial

OBJECTIVE: To investigate the cardiorespiratory, nociceptive and endocrine effects of the combination of propofol and remifentanil, in dogs sedated with acepromazine. STUDY DESIGN: Prospective randomized, blinded, cross-over experimental trial. ANIMALS: Twelve healthy adult female cross-breed dogs, mean weight 18.4 +/- 2.3 kg. METHODS: Dogs were sedated with intravenous (IV) acepromazine (0.05 mg kg(-1) ) followed by induction of anesthesia with IV propofol (5 mg kg(-1) ). Anesthesia was maintained with IV propofol (0.2 mg kg(-1) minute(-1) ) and remifentanil, infused as follows: R1, 0.125 mug kg(-1) minute(-1) ; R2, 0.25 mug kg(-1) minute(-1) ; and R3, 0.5 mug kg(-1) minute(-1) . The same dogs were administered each dose of remifentanil at 1-week intervals. Heart rate (HR), mean arterial pressure (MAP), respiratory rate (f(R) ), end tidal CO(2) (Pe'CO(2) ), arterial hemoglobin O(2) saturation, blood gases, and rectal temperature were measured before induction, and 5, 15, 30, 45, 60, 75, 90, and 120 minutes after beginning the infusion. Nociceptive response was investigated by electrical stimulus (50 V, 5 Hz and 10 ms). Blood samples were collected for plasma cortisol measurements. Statistical analysis was performed by anova (p<0.05). RESULTS: In all treatments, HR decreased during anesthesia with increasing doses of remifentanil, and increased significantly immediately after the end of infusion. MAP remained stable during anesthesia (72-98 mmHg). Antinociception was proportional to the remifentanil infusion dose, and was considered satisfactory only with R2 and R3. Plasma cortisol concentration decreased during anesthesia in all treatments. Recovery was smooth and fast in all dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Infusion of 0.25-0.5 mug kg(-1) minute(-1) remifentanil combined with 0.2 mg kg(-1) minute(-1) propofol produced little effect on arterial blood pressure and led to a good recovery. The analgesia produced was sufficient to control the nociceptive response applied by electrical stimulation, suggesting that it may be appropriate for performing surgery. (c) 2011 The Authors. Veterinary Anaesthesia and Analgesia (c) 2011 Association of Veterinary Anaesthetists and the American College of Veterinary Anesthesiologists.

Page last updated: 2011-12-09

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