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Etomidate shortens the onset time of neuromuscular block.

Author(s): Gill RS, Scott RP

Affiliation(s): Department of Anaesthesia, Odstock Hospital, Salisbury, Wiltshire.

Publication date & source: 1992-11, Br J Anaesth., 69(5):444-6.

Publication type: Clinical Trial; Comparative Study ; Randomized Controlled Trial

We have studied 30 healthy patients allocated randomly to receive thiopentone, propofol or etomidate in equipotent doses followed by vecuronium 0.1 mg kg-1. Haemodynamic variables and time to 100% neuromuscular block were measured. The patients receiving etomidate had a significantly shorter onset time of neuromuscular block compared with those receiving the two other i.v. induction agents. There was a significant negative correlation between onset time of neuromuscular block and the maximum percent change in mean arterial pressure.

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