Effect of sulindac on angiotensin converting enzyme inhibitor-induced cough: randomised placebo-controlled double-blind cross-over study.

Author(s): Gilchrist NL, Richards AM, March R, Nicholls MG

Affiliation(s): Department of Geriatric Medicine, Princess Margaret Hospital, Christchurch, New Zealand.

Publication date & source: 1989-12, J Hum Hypertens., 3(6):451-5.

Publication type: Clinical Trial; Randomized Controlled Trial

The effect of sulindac on ACE inhibitor-induced cough was studied in eight hypertensive subjects in a randomised placebo-controlled double blind cross-over trial. There was no significant improvement in cough or sense of well-being. Blood pressure, renal function, plasma renin and ACE activity were unchanged. Sulindac however, appears to be effective in some individuals in reducing ACE inhibitor-induced cough with acceptable tolerance and few side effects. Further work is needed to elucidate the mechanism of sulindac's interaction with ACE inhibitors.