Ifosfamide/mesna related encephalopathy: a case report with a possible role of phenobarbital in enhancing neurotoxicity.

Author(s): Ghosn M, Carde P, Leclerq B, Flamant F, Friedman S, Droz JP, Hayat M

Affiliation(s): Institut Gustave-Roussy, Villejuif, France.

Publication date & source: 1988, Bull Cancer., 75(4):391-2.

Publication type: Case Reports

A case of reversible encephalopathy after one dose of ifosfamide/mesna in an epileptic 15-year-old girl is reported. No other pathology could be responsible for the symptoms. An epilepsy or a toxicity induced by vincristine were discussed. Nevertheless, the possible role of phenobarbital, known to induce hepatic microsomal activity, seems the more probable mechanism.