Reproducibility of motor effects induced by successive subcutaneous apomorphine injections in Parkinson's disease.

Author(s): Gervason CL, Pollak PR, Limousin P, Perret JE

Affiliation(s): Department of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology U 318, Joseph Fourier University of Grenoble, France.

Publication date & source: 1993-04, Clin Neuropharmacol., 16(2):113-9.

Publication type: Clinical Trial; Randomized Controlled Trial

We performed a crossover study of apomorphine-induced motor response reproducibility in 10 parkinsonian patients with the "on-off" phenomenon. On 2 separate days, each patient received two successive identical s.c. apomorphine injections, the second injection being randomly administered either 10 or 80 min after the end of the first apomorphine-induced motor benefit. Latency (12.3 +/- 4.5 min) and duration (61.9 +/- 13.3 min) of motor effects were similar in all tests. A transient worsening of the parkinsonian state after a motor improvement induced by apomorphine occurred in most of the patients. Therefore, the duration and severity of the "off" period after a motor improvement does not seem to influence the efficacy of a second apomorphine administration.