Risk of thrombogenicity among nonionic radiocontrast agents.
Author(s): Georgakis A, Ener RA, Jin J, Kunapuli S, Fiss D, Leech SH, Wolf NM, Van Decker WA
Affiliation(s): Division of Cardiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA.
Publication date & source: 2008-07, J Invasive Cardiol., 20(7):349-53.
Publication type: Comparative Study
Several contrast agents have been approved in the United States for radiographic imaging purposes. Most of the older ionic, high-osmolar contrast agents are no longer used because of their side effect profile. Therefore, newer nonionic, low or iso-osmolar contrast agents have been widely accepted as an alternative due to their improved tolerability and safety. We investigated the thrombogenicity of the 6 different nonionic radiocontrast media in terms of their platelet reactivity and noted some minor differences among them. In the 50% contrast concentration group, all of the nonionic contrast agents inhibited aggregation, whereas in the 10% contrast concentration group, all agents showed similar aggregation curves in comparison to the normal control. At 50% contrast concentration, the inhibitory effect of aggregation appeared to be related to the inhibition of calcium mobilization, which may be one of the mechanistic effects.