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Inflammation and clinical repercussions of pleurodesis induced by intrapleural talc administration.

Author(s): Genofre EH, Marchi E, Vargas FS

Affiliation(s): Laboratory of Pleura, Pulmonary Division - Heart Institute (InCor)-University of Sao Paulo Medical School, Brazil. ehgenofre@uol.com.br

Publication date & source: 2007-10, Clinics (Sao Paulo)., 62(5):627-34.

Publication type: Review

Although reports on pleurodesis date back to the beginning of the 20th century, the search for the ideal sclerosing agent is ongoing. Several agents have been studied and used, but talc continues to be the most popular. However, potentially harmful systemic side effects have been associated with talc pleurodesis. In this article we discuss the likely mechanisms of pleural inflammation and pleurodesis with emphasis on the systemic response due to the instillation of talc into the pleural space.

Page last updated: 2009-10-20

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