[Ozone therapy combined with sulfasalazine delivered via a colon therapy system for treatment of ulcerative colitis].
Author(s): Geng Y, Wang W, Ma Q, Peng LQ, Liang ZH
Affiliation(s): Department of Gastroenterology, Guangxi, China. firstname.lastname@example.org
Publication date & source: 2010-12, Nan Fang Yi Ke Da Xue Xue Bao., 30(12):2683-5.
Publication type: English Abstract
OBJECTIVE: To assess the therapeutic effect of ozone therapy combined with sulfasalazine sulfasalazine delivered via a colon therapy system in the treatment of distal ulcerative colitis. METHODS: This prospective randomized controlled clinical trial involved 54 patients with mild to moderate active distal ulcerative colitis, who were randomize into 3 groups in accordance with the inclusion criteria (n=18). Each group was given sulfasalazine at the daily dose of 2 g, and in colon therapy group and ozone therapy plus sulfasalazine therapy group, sulfasalazine was delivered via a colon therapy system on a daily basis; the control group received sulfasalazine via retention enema only. At 0, 2, and 4 weeks of the treatment, colonoscopy was performed to evaluate the disease activity, and biopsy samples were obtained at 0 and 4 weeks for histological examination. RESULTS: In comparison with colon therapy group and control group, ozone therapy plus colon therapy resulted in more rapid alleviation of the clinical symptoms and better histological improvement without any adverse effects. CONCLUSION: Ozone therapy combined with sulfasalazine delivered via a colon therapy system is feasible and effective for treatment of ulcerative colitis.