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High-dose versus standard-dose amoxicillin for acute otitis media.

Author(s): Garrison GD, Sorum PC, Hioe W, Miller MM.

Affiliation(s): Department of Pharmacy Practice, Albany College of Pharmacy, Albany, NY 12208, USA. garrisog@acp.edu

Publication date & source: 2004, Ann Pharmacother. , 38(1):15-9

BACKGROUND: Emergence of drug-resistant bacteria has led to a recommendation to use high-dose (HD) amoxicillin (80-90 mg/kg/d) rather than standard-dose (SD) amoxicillin (40-45 mg/kg/d) to treat children with acute otitis media (AOM). OBJECTIVE: To compare the efficacy and tolerability of HD versus SD amoxicillin among children with AOM who were considered at low risk for infection with antibiotic-resistant bacteria. METHODS: A double-blind, randomized, 3-year clinical trial was conducted using participants who met the following criteria: age >3 mo, weight

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