[Activated protein C--recent addition to therapy of sepsis]

Author(s): Gardlund B, Sjolin J

Affiliation(s): Infektionskliniken, Huddinge Universitetssjukhus, Stockholm. bengt.gardlund@hs.se

Publication date & source: 2003-06-26, Lakartidningen., 100(26-27):2292-6.

Publication type: Review

Human recombinant activated protein C (Xigris) represents a new concept in adjuvant therapy for patients with severe sepsis. In the large randomized controlled trial on which the registration is based, 28 day mortality was significantly reduced by 6.1% from 30.8% in the placebo group to 24.7% in the treatment group. Treatment benefit seemed to be restricted to those patients with the most severe disease. Side effects in terms of intracerebral hemorrhage and procedure related bleeding were seen during the 4 day infusion period. Until further data becomes available from ongoing studies, we recommend that treatment be restricted to those patients for whom benefit has been shown in the clinical trial, i.e. adult patients with septic shock and at least one additional sign of organ dysfunction as defined in the study. Patients with septic organ dysfunctions with a longer duration than 24 h were not evaluated in the study.