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Comparison of oral dydrogestrone with progesterone gel and micronized progesterone for luteal support in 1,373 women undergoing in vitro fertilization: a randomized clinical study.

Author(s): Ganesh A, Chakravorty N, Mukherjee R, Goswami S, Chaudhury K, Chakravarty B

Affiliation(s): School of Medical Science and Technology, Indian Institute of Technology, Kharagpur, West Bengal, India.

Publication date & source: 2011-05, Fertil Steril., 95(6):1961-5. Epub 2011 Feb 21.

Publication type: Comparative Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

OBJECTIVE: To compare the efficacy of oral dydrogesterone with that of micronized vaginal P gel and micronized P capsule for luteal supplementation. DESIGN: Prospective, randomized clinical study. SETTING: Institute of Reproductive Medicine, Kolkata, India. PATIENT(S): A total of 1,373 infertile women undergoing IVF participated. INTERVENTION(S): Micronized P gel, P capsule, and oral dydrogesterone were administered for luteal support and compared. MAIN OUTCOME MEASURE(S): Demographic profile and pregnancy and miscarriage rates. RESULT(S): The overall pregnancy rate and miscarriage rate were comparable among the three groups. CONCLUSION(S): Oral dydrogesterone seems to be a promising drug for luteal support in woman undergoing IVF. Copyright (c) 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

Page last updated: 2011-12-09

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