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Simultaneous dissolution profiles of two drugs, sulfadiazine-trimethoprim and amitriptyline-perphenazine, in solid oral dosage forms by a FIA manifold provided with a single spectrophotometric detector.

Author(s): Galvez AM, Mateo JV, Martinez Calatayud J

Affiliation(s): Departamento de Quimica Analitica, Universidad de Valencia, 46100 Valencia, Spain.

Publication date & source: 2002-10-15, J Pharm Biomed Anal., 30(3):535-45.

The simultaneous determination of two dissolution profiles wih the aid of a flow injection analysis assembly has been applied to: (a) sulfadiazine-trimethoprim in tablets and (b) amitriptyline-perphenazine in sugar coated pills. The selected combinations are drugs which have overlapping UV-vis spectra. The officially proposed procedure from the pharmacopoeias has been adapted for the FIA methodology and derivative spectrophotometry and zero crossing. Preliminary experiments on the suitability of the simultaneous determination of both drugs were performed. The empirical profiles were adjusted by regression analysis using different approaches. The 3-parameter plot method was finally selected as the most suitable for the sulfadiazine-trimethoprim and the 4-parameter equation plot for amitriptyline-perphenazine. Copyright 2002 Elsevier Science B.V.

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