Managing intractable migraine with naratriptan.

Author(s): Gallagher RM, Mueller L

Affiliation(s): University Headache Center, Moorestown, NJ 08057, USA.

Publication date & source: 2003-10, Headache., 43(9):991-3.

Publication type:

BACKGROUND: Intractable migraine presents a significant treatment challenge to both patient and physician. Most attacks are treatable or self-limiting, but occasionally they may continue for extended periods regardless of treatment. OBJECTIVE: To determine the efficacy of naratriptan 2.5 mg twice daily for the treatment of intractable migraine. METHODS: We reviewed 24 patients treated with naratriptan twice daily for an intractable migraine attack. Patients were permitted to take prophylactic medication if such treatment had been effective in the past. RESULTS: Nineteen patients (79%) improved. Twelve patients showed excellent response with cessation of pain and associated symptoms, 7 patients partially responded with lessening of pain and cessation of associated symptoms, and 5 patients were nonresponsive. CONCLUSION: Short-term daily administration of naratriptan may be effective in terminating status migrainosus.