Effects of timolol and dorzolamide on retrobulbar hemodynamics in patients with newly diagnosed primary open-angle glaucoma.

Author(s): Galassi F, Sodi A, Renieri G, Ucci F, Pieri B, Harris A, Siesky B

Affiliation(s): Department of Oto-Neuro-Ophthalmological Surgery, Section of Ophthalmology, University of Florence, Italy. fernando.galassi@unifi.it

Publication date & source: 2002-03, Ophthalmologica., 216(2):123-8.

Publication type: Clinical Trial; Randomized Controlled Trial

The authors considered a group of patients with newly diagnosed primary open-angle glaucoma studying the effects of a 4-week treatment with timolol or dorzolamide on retrobulbar vessels. Ocular hemodynamics were assessed by means of color Doppler imaging of the ophthalmic artery, the temporal short posterior ciliary arteries (SPCAs) and the central retinal artery. For each vessel, systolic and diastolic blood flow velocities were measured, and the resistivity index (RI) was calculated. The only significant result was a reduction of temporal SPCA RI after dorzolamide treatment in comparison with baseline (p = 0.011). In the same group, dorzolamide treatment had a slight and nonsignificant increase in temporal SPCA diastolic velocity. The resistance decrease observed after dorzolamide treatment in the ciliary circulation may be due to the decrease in intraocular pressure or a possible direct vasodilating effect of the drug. Copyright 2002 S. Karger AG, Basel