Effect of furosemide on angiotensin II-mediated prostaglandin I2 production in
hypertensive subjects.
Author(s): Fujimura A(1), Ebihara A.
Affiliation(s): Author information:
(1)Department of Clinical Pharmacology, Jichi Medical School, Tochigi, Japan.
Publication date & source: 1990, Eur J Clin Pharmacol. , 39(2):113-5
The role of angiotensin II (AII) in Prostaglandin I2 (PGI2) production following
furosemide has been examined in a placebo-controlled, cross-over study.
Furosemide 20 mg was injected intravenously in eight hypertensive subjects
already treated with oral captopril 25 mg or a matching placebo. Urinary
excretion of 6-keto-PGF1 alpha (a metabolite of PGI2) and PGE2, PRA and AII was
increased following furosemide without captopril pretreatment. The rises in
urinary 6-keto-PGF1 alpha and PGE2, and plasma AII after furosemide were
prevented by the captopril pretreatment. Urinary volume, sodium and furosemide
were not affected by captopril. The data indicate that the effect of furosemide
on PGI2 production, as reflected by the urinary excretion of 6-keto-PGF1 alpha,
was mediated by an action of AII.
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