[Effectiveness and time to onset of pregabalin in patients with neuropathic pain]
Author(s): Freynhagen R, Busche P, Konrad C, Balkenohl M
Affiliation(s): Klinik fur Anasthesiologie, Universitatsklinikum Dusseldorf. Freynhagen@med.uni-duesseldorf.de
Publication date & source: 2006-08, Schmerz., 20(4):285-8, 290-2.
Publication type: Comparative Study; English Abstract; Multicenter Study; Randomized Controlled Trial
BACKGROUND: The data from a previously published 12-week randomised, double-blind, placebo-controlled multicentre study on the efficacy and safety of pregabalin were analyzed for time to onset of analgesic action with neuropathic pain. PATIENTS AND METHODS: A total of 338 patients with postherpetic neuralgia or painful diabetic peripheral neuropathy were treated with flexible or fixed regimens of pregabalin at daily doses of up to 600 mg/day (n=141 and 132, respectively) or placebo (n=65). RESULTS: Under fixed dose treatment, a decrease of one full point on the 11-point numerical rating pain scale was reached on day 1, two full points on day 13, and three full points on day 23 (under flexible dose pregabalin: on days 6, 17 and 30). In both treatment arms, pain reduction was statistically significant (P=0.001, P=0.002 vs placebo, respectively). CONCLUSION: In patients with chronic neuropathic pain, the analgesic effect of both pregabalin treatment regimens was high and associated with a rapid time to onset.