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Intravitreal ranibizumab and bevacizumab in combination with full-fluence verteporfin therapy and dexamethasone for exudative age-related macular degeneration.

Author(s): Forte R, Bonavolonta P, Benayoun Y, Adenis JP, Robert PY

Affiliation(s): Eye Department, University Federico II, Naples, Italy. raifor@hotmail.com

Publication date & source: 2011, Ophthalmic Res., 45(3):129-34. Epub 2010 Sep 17.

Publication type: Comparative Study; Evaluation Studies

PURPOSE: To evaluate the efficacy and safety of triple therapy with intravitreal anti-vascular-endothelial-growth-factor (VEGF) antibody, dexamethasone and verteporfin photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD). METHODS: Retrospective, comparative, interventional study. Records of treatment-naive patients who received intravitreal bevacizumab or ranibizumab in monotherapy or in combination with dexamethasone and full-fluence verteporfin PDT in triple therapy were reviewed. logMAR visual acuity, foveal thickness (FT) on optical coherence tomography, intraocular pressure and endophthalmitis occurrence were recorded. RESULTS: Sixty-one eyes were included in the triple-therapy group, 40 eyes were included in the monotherapy group. The mean follow-up was 14.1 +/- 3.4 months in the triple-therapy group and 16.3 +/- 4.1 months in the monotherapy group. The triple-therapy group enjoyed a lower total number of treatments (1.92 +/- 0.44 vs. 3.12 +/- 0.37, p < 0.001) and a longer time before first retreatment (5.4 +/- 3.3 vs. 3.6 +/- 2.5 months, p = 0.001). A significant improvement of visual acuity and FT was present in both groups during the 12 months following first treatment. No adverse effects were observed. CONCLUSION: The combination of intravitreal bevacizumab or ranibizumabwith dexamethasone and full-fluence PDT for exudative AMD provided visual and anatomic improvement and a good safety profile. Triple therapy may reduce the number of retreatments when compared to anti-VEGF alone. Copyright (c) 2010 S. Karger AG, Basel.

Page last updated: 2011-12-09

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