Detection of massive transplacental haemorrhage by flow cytometry.
Author(s): Fong EA, Davies JI, Grey DE, Reid PJ, Erber WN
Affiliation(s): Haematology, Western Australian Centre for Pathology and Medical Research, Nedlands WA, Australia.
Publication date & source: 2000-12, Clin Lab Haematol., 22(6):325-7.
Publication type: Case Reports
Flow cytometry has been shown to be a more accurate and sensitive method than the Kleihauer-Betke test for the measurement of feto-maternal haemorrhage in Rh(D) incompatibility. This report describes the successful use of flow cytometry to detect and monitor the management of a massive transplacental haemorrhage (105 ml) of fetal Rh(D) positive cells in a Rh(D) negative woman. The report highlights the accuracy and reproducibility of the test and the stability of a blood sample when transferred 596 kilometres to a central testing facility.