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Topiramate for the treatment of alcohol dependence: comparison with naltrexone.

Author(s): Florez G, Saiz PA, Garcia-Portilla P, Alvarez S, Nogueiras L, Bobes J

Affiliation(s): Department of Psychiatry, University of Oviedo, Centro de Investigacion Biomedica en Red de Salud Mental, CIBERSAM, Oviedo, Spain. gerardo.florez.menendez@sergas.es

Publication date & source: 2011, Eur Addict Res., 17(1):29-36. Epub 2010 Oct 26.

Publication type: Comparative Study; Randomized Controlled Trial

BACKGROUND: A 6-month naturalistic, randomized and open-label, trial of topiramate versus naltrexone was conducted, with assessments at enrollment and after 3 and 6 months of treatment. 182 alcohol-dependent patients who had been drinking heavily during the past month were included. METHODS: Outcome was measured using tools that assessed alcohol intake, cravings, disability, and quality of life; changes in biomarkers of alcohol intake were also used. RESULTS: At the 6-month evaluation, patients taking topiramate had significantly lower scores on the OCDS (all subscales), the EuropASI (medical, alcohol, family/social, and psychiatric) and the WHO/DAS (employment/social). More patients taking topiramate remained in the abstinence group and the moderate drinking without problems group. CONCLUSIONS: Topiramate at a mean dose of 200 mg/day was better than naltrexone at a mean dose of 50 mg/day at reducing alcohol intake and cravings throughout the study. Copyright (c) 2010 S. Karger AG, Basel.

Page last updated: 2011-12-09

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